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Antimicrob Agents Chemother. 2011 Apr;55(4):1761-3. doi: 10.1128/AAC.01175-10. Epub 2011 Jan 24.

Penetration of topically administered 0.5-percent caspofungin eye drops into human aqueous humor.

Author information

1
Department of Pharmacy Practice, Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia.

Abstract

Ten participants attending elective anterior segment eye surgery received 0.5% caspofungin eye drops either 1 drop hourly for 4 h or 1 drop an hour before surgery. The eye drops were generally well tolerated. In the absence of inflammation or corneal abrasion, topical caspofungin does not achieve clinically relevant concentrations.

PMID:
21263052
PMCID:
PMC3067136
DOI:
10.1128/AAC.01175-10
[Indexed for MEDLINE]
Free PMC Article

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