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J Cell Biol. 2011 Jan 24;192(2):209-18. doi: 10.1083/jcb.201009059.

p53 and its mutants in tumor cell migration and invasion.

Author information

1
Beatson Institute for Cancer Research, Glasgow G61 1BD, Scotland, UK.

Abstract

In about half of all human cancers, the tumor suppressor p53 protein is either lost or mutated, frequently resulting in the expression of a transcriptionally inactive mutant p53 protein. Loss of p53 function is well known to influence cell cycle checkpoint controls and apoptosis. But it is now clear that p53 regulates other key stages of metastatic progression, such as cell migration and invasion. Moreover, recent data suggests that expression of mutant p53 is not the equivalent of p53 loss, and that mutant p53s can acquire new functions to drive cell migration, invasion, and metastasis, in part by interfering with p63 function.

PMID:
21263025
PMCID:
PMC3172183
DOI:
10.1083/jcb.201009059
[Indexed for MEDLINE]
Free PMC Article

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