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Brain Res Dev Brain Res. 1990 Oct 1;56(1):131-6.

The p38 and p34 polypeptides of growth cone particle membranes are the alpha- and beta-subunits of G proteins.

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Howard Hughes Medical Institute, University of Texas Southwestern Medical School, Dallas 75235-9050.


Growth cone particle (GCP) membranes prepared from fetal day 17 rat brain are comprised of 5 major polypeptides as analyzed by SDS-PAGE: tubulin (p52), actin (p42), pp46/GAP-43 and two unidentified species, p38 and p34. Antibodies specific for the alpha- and beta-subunits of G proteins recognize p38 and p34, respectively, on immunoblots following one- and two-dimensional electrophoretic separation. That G protein subunits comprise major species of GCP membrane-associated polypeptides suggests a role for G proteins in transmembrane signaling in nerve growth cones.

[Indexed for MEDLINE]

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