(a) The domain organization of IgG1showing the antigen-binding Fab fragments, the Fc fragment, and the N-glycan. (b) The Fc glycan as remodeled in this work is predominantly a galactose-terminated complex-type, biantennary, fucosylated carbohydrate. Open circles indicate galactose, filled squares N-acetylglucosamine, grey circles mannose, and open triangles fucose residues.