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J Biol Chem. 2011 Mar 25;286(12):9905-12. doi: 10.1074/jbc.R110.173260. Epub 2011 Jan 21.

The giant protein titin: a regulatory node that integrates myocyte signaling pathways.

Author information

1
Department of Cardiovascular Physiology, Ruhr University Bochum, D-44780 Bochum, Germany. martina.krueger@rub.de

Abstract

Titin, the largest protein in the human body, is well known as a molecular spring in muscle cells and scaffold protein aiding myofibrillar assembly. However, recent evidence has established another important role for titin: that of a regulatory node integrating, and perhaps coordinating, diverse signaling pathways, particularly in cardiomyocytes. We review key findings within this emerging field, including those related to phosphorylation of the titin springs, and also discuss how titin participates in hypertrophic gene regulation and protein quality control.

PMID:
21257761
PMCID:
PMC3060543
DOI:
10.1074/jbc.R110.173260
[Indexed for MEDLINE]
Free PMC Article
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