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Transfus Apher Sci. 2011 Feb;44(1):65-72. doi: 10.1016/j.transci.2010.12.011. Epub 2011 Jan 22.

DNA-based methods in the immunohematology reference laboratory.

Author information

1
Laboratory of Immunochemistry, New York Blood Center, 310 East 67th Street, New York, NY 10065, United States. mreid@nybloodcenter.org

Abstract

Although hemagglutination serves the immunohematology reference laboratory well, when used alone, it has limited capability to resolve complex problems. This overview discusses how molecular approaches can be used in the immunohematology reference laboratory. In order to apply molecular approaches to immunohematology, knowledge of genes, DNA-based methods, and the molecular bases of blood groups are required. When applied correctly, DNA-based methods can predict blood groups to resolve ABO/Rh discrepancies, identify variant alleles, and screen donors for antigen-negative units. DNA-based testing in immunohematology is a valuable tool used to resolve blood group incompatibilities and to support patients in their transfusion needs.

PMID:
21257350
PMCID:
PMC3058268
DOI:
10.1016/j.transci.2010.12.011
[Indexed for MEDLINE]
Free PMC Article
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