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Cytokine. 2011 Apr;54(1):6-19. doi: 10.1016/j.cyto.2010.12.019. Epub 2011 Jan 22.

The CCAAT/enhancer (C/EBP) family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation.

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1
Cancer Chemotherapy Center and Hematology, University of Occupational and Environmental Health, Kitakyushu, Japan.

Abstract

The C/EBP family of proteins represents an important group of bZIP transcription factors that are key to the regulation of essential functions such as cell cycle, hematopoiesis, skeletal development, and host immune responses. They are also intimately associated with tumorigenesis and viral disease. These proteins are regulated at multiple levels, including gene induction, alternative translational initiation, post-translational modification, and protein-protein interaction. This review attempts to integrate recent reports with more than 20 years of previous effort focused on this fascinating collection of regulators.

PMID:
21257317
DOI:
10.1016/j.cyto.2010.12.019
[Indexed for MEDLINE]

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