Format

Send to

Choose Destination
Bioorg Med Chem. 2011 Feb 1;19(3):1167-71. doi: 10.1016/j.bmc.2010.12.051. Epub 2010 Dec 30.

Benzyl benzoates: New phlorizin analogs as mushroom tyrosinase inhibitors.

Author information

1
Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Sun Yat-sen University, PR China.

Abstract

In our research, 14 benzyl benzoates with hydroxyl(s) (3-16) were synthesized and their inhibitory activity on mushroom tyrosinase was tested. Results indicated that among these compounds, 4-hydroxybenzyl 3,5-dihydroxybenzoate (3), 4-hydroxybenzyl 2,4-dihydroxybenzoate (5), 4-hydroxybenzyl 2,4,6-dihydroxybenzoate (7), 3-hydroxybenzyl 3,5-dihydroxybenzoate (8), 3-hydroxybenzyl 2,4-dihydroxybenzoate (10) exhibited inhibitory activity with their IC(50) less than 10μM. Further studies showed these five compounds were competitive inhibitors of tyrosinase and their structure-activity relationships were investigated in this article.

PMID:
21256757
DOI:
10.1016/j.bmc.2010.12.051
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center