Format

Send to

Choose Destination
See comment in PubMed Commons below
Cardiovasc Pathol. 2011 May-Jun;20(3):177-82. doi: 10.1016/j.carpath.2010.12.001. Epub 2011 Jan 20.

The aortic valve microenvironment and its role in calcific aortic valve disease.

Author information

1
Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada.

Abstract

In calcific aortic valve disease, fibrotic and calcific lesions form focally in the fibrosa layer of the valve leaflets. Layer-specific pathosusceptibility suggests that the fibrosa microenvironment is permissive to pathological development. The cellular microenvironment in the aortic valve is defined by a variety of biomechanical-, biochemical-, and extracellular-mediated factors, some of which are unique to the fibrosa. Growing evidence supports the role of these microenvironmental cues in the local regulation of side-specific valve cell phenotypes and focal pathological alterations, revealing new insights into the cellular and molecular processes that contribute to calcific aortic valve disease.

PMID:
21256052
DOI:
10.1016/j.carpath.2010.12.001
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center