Format

Send to

Choose Destination
Mol Cell. 2011 Jan 21;41(2):150-60. doi: 10.1016/j.molcel.2010.11.030.

The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes.

Author information

1
Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616, USA.

Abstract

In mammals, fusion of the mitochondrial outer membrane is controlled by two DRPs, MFN1 and MFN2, that function in place of a single outer membrane DRP, Fzo1 in yeast. We addressed the significance of two mammalian outer membrane fusion DRPs using an in vitro mammalian mitochondrial fusion assay. We demonstrate that heterotypic MFN1-MFN2 trans complexes possess greater efficacy in fusion as compared to homotypic MFN1 or MFN2 complexes. In addition, we show that the soluble form of the proapoptotic Bcl2 protein, Bax, positively regulates mitochondrial fusion exclusively through homotypic MFN2 trans complexes. Together, these data demonstrate functional and regulatory distinctions between MFN1 and MFN2 and provide insight into their unique physiological roles.

PMID:
21255726
PMCID:
PMC3072068
DOI:
10.1016/j.molcel.2010.11.030
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center