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Semin Oncol Nurs. 2011 Feb;27(1):21-33. doi: 10.1016/j.soncn.2010.11.004.

Germline mutations in cancer susceptibility genes: an overview for nurses.

Author information

1
Division of Clinical Cancer Genetics, Department of Population Science, City of Hope Comprehensive Cancer Center, 1500 E. Duarte Road, Duarte, CA 91010, USA. dmacdonald@coh.org

Abstract

OBJECTIVE:

To provide an overview of hereditary cancer susceptibility genes and associated cancer risks.

DATA SOURCES:

Peer reviewed published research studies and review articles.

CONCLUSIONS:

Identifying deleterious mutations in cancer susceptibility genes allows for clarification of cancer risk in individual family members and risk-level appropriate screening, and risk management recommendations. Evolving knowledge of the role of germline mutations provides an unprecedented opportunity to reduce cancer incidence, morbidity, and morality.

IMPLICATIONS FOR NURSING PRACTICE:

To provide individuals/families with accurate cancer risk management information and guidance, oncology nurses must be familiar with scientific discoveries related to cancer susceptibility genes.

PMID:
21255710
DOI:
10.1016/j.soncn.2010.11.004
[Indexed for MEDLINE]
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