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Vaccine. 2011 Mar 3;29(11):2044-50. doi: 10.1016/j.vaccine.2011.01.010. Epub 2011 Jan 19.

Kinetic study of the antibody response during the blood meal of Ixodes ricinus: implication on plasma cell maturation in vivo and for anti-Ixodes vaccination.

Author information

1
Laboratory of Human Histology - Centre de recherche sur les protéines Prion (CRPP), University of Liege, Avenue de l'Hopital, 1, B-4000 Liege, Belgium. C.Dedoyart@chu.ulg.ac.be

Abstract

Anti-tick vaccination could be an ideal solution to prevent pathogen transmission, but none is currently available against Ixodes ticks. Recently, we showed that adult Ixodes ricinus infestation on mice decreases the specific antibody production to BSA injected during infestation. Here, a kinetic study of seric levels of BSA-specific antibodies was performed to evaluate the B memory cell differentiation in Balb/c mice and the capacity of specific B memory cells to respond to BSA during infestation. We concluded that the tick blood meal inhibits or impairs the local differentiation of mature B cells into plasma cells, but does not alter the formation of memory B cell. Accordingly, this mechanism should not be an impediment to anti-Ixodes vaccination.

PMID:
21255683
DOI:
10.1016/j.vaccine.2011.01.010
[Indexed for MEDLINE]

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