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J Dermatolog Treat. 2012 Feb;23(1):11-5. doi: 10.3109/09546634.2010.512952. Epub 2011 Jan 22.

Efficacy of clobetasol spray: factors beyond patient compliance.

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University of California, Department of Dermatology, San Francisco, San Francisco, CA, USA.


Clobetasol 0.05% spray, a topical clobetasol propionate, is a non-greasy formulation that has shown increased clinical efficacy in a head-to-head comparison with foam formulation. Moreover, available data from randomized, controlled, double-blind trials suggests that clobetasol spray is, in fact, slightly more effective than most, if not all, other preparations of clobetasol. The fact that clobetasol spray is exceptionally easy to comply with may have played a major role in this outcome; however, other factors must be considered. These include vehicle metamorphosis post-application as well as vehicle and excipient effects on stratum corneum permeability. Basic concepts in topical drug delivery and how they apply to this spray vehicle may further explain the greater efficacy of clobetasol spray.

[Indexed for MEDLINE]

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