Synthesis and secretion of Alzheimer amyloid beta A4 precursor protein by stimulated human peripheral blood leucocytes

FEBS Lett. 1990 Dec 17;277(1-2):261-6. doi: 10.1016/0014-5793(90)80861-c.

Abstract

Alzheimer amyloid precursor proteins (APP) are actively secreted by stimulated human peripheral mononuclear blood leucocytes (PMBLs). Induction of APP transcription, translation and secretion was observed with several T cell mitogens but was highest with phytohemagglutinin. The time course of induction is similar to that reported for IL-2 and IL-2 receptor. We suggest that APP may play an important role in the construction of the immunological network and the differentiation of T cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amyloid beta-Peptides / genetics
  • Amyloid beta-Peptides / metabolism*
  • Amyloid beta-Protein Precursor
  • Concanavalin A / pharmacology
  • Gene Expression / drug effects
  • Humans
  • In Vitro Techniques
  • Leukocytes, Mononuclear / metabolism*
  • Lymphocyte Activation
  • Lymphocytes / metabolism
  • Myositis / immunology
  • Myositis / metabolism
  • Phytohemagglutinins / pharmacology
  • Pokeweed Mitogens / pharmacology
  • Protein Precursors / genetics
  • Protein Precursors / metabolism*
  • RNA, Messenger / genetics

Substances

  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Phytohemagglutinins
  • Pokeweed Mitogens
  • Protein Precursors
  • RNA, Messenger
  • Concanavalin A