Abstract
Alzheimer amyloid precursor proteins (APP) are actively secreted by stimulated human peripheral mononuclear blood leucocytes (PMBLs). Induction of APP transcription, translation and secretion was observed with several T cell mitogens but was highest with phytohemagglutinin. The time course of induction is similar to that reported for IL-2 and IL-2 receptor. We suggest that APP may play an important role in the construction of the immunological network and the differentiation of T cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amyloid beta-Peptides / genetics
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Amyloid beta-Peptides / metabolism*
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Amyloid beta-Protein Precursor
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Concanavalin A / pharmacology
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Gene Expression / drug effects
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Humans
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In Vitro Techniques
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Leukocytes, Mononuclear / metabolism*
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Lymphocyte Activation
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Lymphocytes / metabolism
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Myositis / immunology
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Myositis / metabolism
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Phytohemagglutinins / pharmacology
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Pokeweed Mitogens / pharmacology
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Protein Precursors / genetics
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Protein Precursors / metabolism*
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RNA, Messenger / genetics
Substances
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Amyloid beta-Peptides
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Amyloid beta-Protein Precursor
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Phytohemagglutinins
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Pokeweed Mitogens
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Protein Precursors
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RNA, Messenger
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Concanavalin A