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Med Princ Pract. 2011;20(2):142-6. doi: 10.1159/000319907. Epub 2011 Jan 20.

Bixa orellana leaves extract inhibits bradykinin-induced inflammation through suppression of nitric oxide production.

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1
Department of Biomedical Sciences, Universiti Putra Malaysia, Serdang, Malaysia.

Abstract

OBJECTIVE:

The present study was conducted to assess the anti-inflammatory effect of a crude aqueous extract of Bixa orellana leaves (AEBO) and to examine the possible involvement of nitric oxide (NO) in its anti-inflammatory mechanism.

MATERIALS AND METHODS:

The air-dried, powdered leaves were soaked in distilled water (1:20 w/v) at 50°C for 24 h and the supernatant obtained was freeze-dried (yield 8.5% w/w). The dosage was recorded as the mass of extract per kg b.w. of rats in all inflammatory assays (bradykinin-induced paw edema, peritoneal vascular permeability and NO assay).

RESULTS:

Pretreatment with AEBO for 4 consecutive days exhibited significant inhibitory activity against inflammatory models, the bradykinin-induced hind paw edema model and bradykinin-induced increased peritoneal vascular permeability at both doses in dose-dependent manner. In addition, AEBO was also found to significantly suppress the production of NO at doses of 50 and 150 mg/kg.

CONCLUSION:

This study provides scientific data to support the traditional use of B. orellana leaves in treating inflammation. Results from this study suggest that AEBO exerts anti-inflammatory effects. Part of this anti-inflammatory effect may be associated with its antibradykinin activity and may be related to a reduction of the NO production.

PMID:
21252569
DOI:
10.1159/000319907
[Indexed for MEDLINE]
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