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Cancer Cell. 2011 Jan 18;19(1):9-10. doi: 10.1016/j.ccr.2011.01.007.

Human acute myelogenous leukemia stem cells revisited: there's more than meets the eye.

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1
Department of Internal Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA. rmajeti@stanford.edu

Abstract

In this issue of Cancer Cell, Goardon et al. revise earlier conclusions regarding acute myelogenous leukemia (AML) stem cells by demonstrating that in the majority of patients, they reside in two hierarchically related populations most similar to normal hematopoietic progenitors. These findings have implications for therapeutic targeting of these cells.

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