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Cancer Cell. 2011 Jan 18;19(1):6-8. doi: 10.1016/j.ccr.2011.01.003.

Metastatic colon cancer cells negotiate the intravasation Notch.

Author information

1
Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH-4058 Basel, Switzerland. gerhard.christofori@unibas.ch

Abstract

In this issue of Cancer Cell, Sonoshita et al. report that Aes/Grg5 prevents metastasis of colorectal cancer cells by sequestering and inactivating Notch transcriptional effectors in distinct nuclear foci. Loss of Aes/Grg5 in invasive cancer cells where Notch is activated by stroma-expressed ligands promotes invasion, transendothelial migration, intravasation, and metastasis.

PMID:
21251610
DOI:
10.1016/j.ccr.2011.01.003
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