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Cancer Cell. 2011 Jan 18;19(1):3-4. doi: 10.1016/j.ccr.2011.01.004.

Hard times for oncogenic BRAF-expressing melanoma cells.

Author information

1
Molecular Pharmacology Group, Institute of Neuroscience and Psychology, CMVLS, Wolfson Link and Davidson Buildings, University of Glasgow, Glasgow G12 8QQ, Scotland, UK. miles.houslay@glasgow.ac.uk

Abstract

In this issue of Cancer Cell, Arozarena et al. describe that the oncogenic BRAF Val600Glu mutant, which occurs in about half of melanomas, downregulates the cGMP-hydrolysing phosphodiesterase PDE5A in melanoma cells through the ERK-MAPK cascade coupled to the POU-domain transcription factor BRN2, thereby increasing intracellular cGMP levels and promoting invasiveness.

PMID:
21251608
DOI:
10.1016/j.ccr.2011.01.004
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