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Crit Rev Biochem Mol Biol. 2011 Feb;46(1):41-66. doi: 10.3109/10409238.2010.538663.

Probing bacterial pathogenesis with genetics, genomics, and chemical biology: past, present, and future approaches.

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1
The Broad Institute of MIT and Harvard, Cambridge, MA, USA.

Abstract

Classical genetic approaches for studying bacterial pathogenesis have provided a solid foundation for our current understanding of microbial physiology and the interactions between pathogen and host. During the past decade however, advances in several arenas have expanded the ways in which the biology of pathogens can be studied. This review discussed the impact of these advances on bacterial genetics, including the application of genomics and chemical biology to the study of pathogenesis.

PMID:
21250782
DOI:
10.3109/10409238.2010.538663
[Indexed for MEDLINE]

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