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The Brighton Collaboration: Creating a Global Standard for Case Definitions (and Guidelines) for Adverse Events Following Immunization.


Kohl KS3, Bonhoeffer J3, Braun MM3, Chen RT3, Duclos P3, Heijbel H3, Heininger U3, Loupi E3, Marcy SM3; The Brighton Collaboration3.


In: Henriksen K1, Battles JB1, Marks ES2, Lewin DI1, editors.


Advances in Patient Safety: From Research to Implementation (Volume 2: Concepts and Methodology). Rockville (MD): Agency for Healthcare Research and Quality (US); 2005 Feb.
Advances in Patient Safety.

Author information

Agency for Healthcare Research and Quality
US Department of Defense
Centers for Disease Control and Prevention, Atlanta, GA (KSK, RTC). University Children's Hospital Basel, Switzerland (JB, UH). Food and Drug Administration, Rockville, MD (MMB). World Health Organization, Geneva, Switzerland (PD). Swedish Institute for Infectious Disease Control, Stockholm, Sweden (HH). Aventis Pasteur, S.A, Lyon, France (EL). UCLA Center for Vaccine Research, Kaiser Foundation Hospital, Los Angeles California (SMM)


Background: To advance the science of immunization safety and “vaccinovigilance,” a globally acceptable, common vocabulary for adverse events following immunization (AEFIs) is needed to promote comparability of data. Methods: The Brighton Collaboration develops standardized case definitions and guidelines for data collection, analysis, and presentation via participation of more than 500 experts from 57 countries from public health, clinical care, academia, regulatory organizations, and industry. Results: The first six Brighton case definitions and guidelines have been finalized. Work continues on 17 additional topics. Formal evaluation studies of definitions are underway. More than 67 investigators in 30 countries have begun or are considering implementation of the definitions and guidelines. Conclusions: Standardized and globally implemented case definitions and guidelines for AEFIs will enhance comparability of vaccine safety data and ultimately maintain trust in immunization programs worldwide. The Brighton Collaboration may be a useful model for other realms of patient safety.

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