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Nature. 2011 Jan 20;469(7330):336-42. doi: 10.1038/nature09783.

Pervasive roles of microRNAs in cardiovascular biology.

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1
Department of Molecular Biology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9148, USA.

Abstract

First recognized as regulators of development in worms and fruitflies, microRNAs are emerging as pivotal modulators of mammalian cardiovascular development and disease. Individual microRNAs modulate the expression of collections of messenger RNA targets that often have related functions, thereby governing complex biological processes. The wideranging functions of microRNAs in the cardiovascular system have provided new perspectives on disease mechanisms and have revealed intriguing therapeutic targets, as well as diagnostics, for a variety of cardiovascular disorders.

PMID:
21248840
PMCID:
PMC3073349
DOI:
10.1038/nature09783
[Indexed for MEDLINE]
Free PMC Article

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