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Nature. 2011 Jan 20;469(7330):323-35. doi: 10.1038/nature09782.

Autophagy in immunity and inflammation.

Author information

1
Department of Microbiology, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9113, USA. beth.levine@utsouthwestern.edu

Abstract

Autophagy is an essential, homeostatic process by which cells break down their own components. Perhaps the most primordial function of this lysosomal degradation pathway is adaptation to nutrient deprivation. However, in complex multicellular organisms, the core molecular machinery of autophagy - the 'autophagy proteins' - orchestrates diverse aspects of cellular and organismal responses to other dangerous stimuli such as infection. Recent developments reveal a crucial role for the autophagy pathway and proteins in immunity and inflammation. They balance the beneficial and detrimental effects of immunity and inflammation, and thereby may protect against infectious, autoimmune and inflammatory diseases.

PMID:
21248839
PMCID:
PMC3131688
DOI:
10.1038/nature09782
[Indexed for MEDLINE]
Free PMC Article

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