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Nat Rev Neurosci. 2011 Feb;12(2):73-87. doi: 10.1038/nrn2977.

The role of G protein-coupled receptors in the pathology of Alzheimer's disease.

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1
Department for Molecular and Developmental Genetics, Flanders Institute for Biotechnology (VIB), Leuven, Belgium. Amantha.Thathiah@cme.vibkuleuven.be

Abstract

G protein-coupled receptors (GPCRs) are involved in numerous key neurotransmitter systems in the brain that are disrupted in Alzheimer's disease (AD). GPCRs also directly influence the amyloid cascade through modulation of the α-, β- and γ-secretases, proteolysis of the amyloid precursor protein (APP), and regulation of amyloid-β degradation. Additionally, amyloid-β has been shown to perturb GPCR function. Emerging insights into the mechanistic link between GPCRs and AD highlight the potential of this class of receptors as a therapeutic target for AD.

PMID:
21248787
DOI:
10.1038/nrn2977
[Indexed for MEDLINE]
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