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Nat Rev Cancer. 2011 Feb;11(2):111-21. doi: 10.1038/nrc3002. Epub 2011 Jan 20.

Wilms' tumours: about tumour suppressor genes, an oncogene and a chameleon gene.

Author information

1
Department of Genetics, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. vhuff@mdacc.tmc.edu

Abstract

Genes identified as being mutated in Wilms' tumour include TP53, a classic tumour suppressor gene (TSG); CTNNB1 (encoding β-catenin), a classic oncogene; WTX, which accumulating data indicate is a TSG; and WT1, which is inactivated in some Wilms' tumours, similar to a TSG. However, WT1 does not always conform to the TSG label, and some data indicate that WT1 enhances cell survival and proliferation, like an oncogene. Is WT1 a chameleon, functioning as either a TSG or an oncogene, depending on cellular context? Are these labels even appropriate for describing and understanding the function of WT1?

PMID:
21248786
PMCID:
PMC4332715
DOI:
10.1038/nrc3002
[Indexed for MEDLINE]
Free PMC Article

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