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Virology. 2011 Mar 15;411(2):260-72. doi: 10.1016/j.virol.2010.12.039. Epub 2011 Jan 17.

Stem cell-based anti-HIV gene therapy.

Author information

1
The David Geffen School of Medicine, University of California, Los Angeles, CA, USA.

Abstract

Human stem cell-based therapeutic intervention strategies for treating HIV infection have recently undergone a renaissance as a major focus of investigation. Unlike most conventional antiviral therapies, genetically engineered hematopoietic stem cells possess the capacity for prolonged self-renewal that would continuously produce protected immune cells to fight against HIV. A successful strategy therefore has the potential to stably control and ultimately eradicate HIV from patients by a single or minimal treatment. Recent progress in the development of new technologies and clinical trials sets the stage for the current generation of gene therapy approaches to combat HIV infection. In this review, we will discuss two major approaches that are currently underway in the development of stem cell-based gene therapy to target HIV: one that focuses on the protection of cells from productive infection with HIV, and the other that focuses on targeting immune cells to directly combat HIV infection.

PMID:
21247612
PMCID:
PMC3072166
DOI:
10.1016/j.virol.2010.12.039
[Indexed for MEDLINE]
Free PMC Article

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