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Expert Opin Pharmacother. 2011 May;12(7):1099-109. doi: 10.1517/14656566.2011.548806. Epub 2011 Jan 20.

Treating tension-type headache -- an expert opinion.

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University of Copenhagen, Glostrup Hospital, Danish Headache Centre, Department of Neurology,Glostrup, Copenhagen, Denmark.



Tension-type headache (TTH) is a highly prevalent disorder with enormous costs for the individual and the society.


Nonpharmacological and pharmacological treatments are reviewed. Electromyographic (EMG) biofeedback has a documented effect in TTH, while cognitive-behavioral therapy and relaxation training are most likely to be effective. Physical therapy and acupuncture may be valuable options for patients with frequent TTH. Simple analgesics and nonsteroidal anti-inflammatory drugs are recommended for treatment of episodic TTH. Combination analgesics containing caffeine are drugs of second choice. Triptans, muscle relaxants and opioids should not be used. It is crucial to avoid frequent and excessive use of analgesics to prevent the development of medication-overuse headache. The tricyclic antidepressant amitriptyline is the drug of first choice for the prophylactic treatment of chronic TTH. Mirtazapine and venlafaxine are second-choice drugs.


There is an urgent need for more research in nonpharmacological as well as pharmacological treatment possibilities of TTH. Future studies should examine the relative efficacy of the various treatment modalities and clarify how treatment programs can be optimized and combined to best suit the individual patient. Frequent TTH may be difficult to treat, but an acceptable result can usually be obtained by a combination of nonpharmacological and pharmacological treatments.

[Indexed for MEDLINE]

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