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Org Lett. 2011 Feb 18;13(4):752-5. doi: 10.1021/ol102991d. Epub 2011 Jan 19.

Sceliphrolactam, a polyene macrocyclic lactam from a wasp-associated Streptomyces sp.

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1
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Abstract

A previously unreported 26-membered polyene macrocyclic lactam, sceliphrolactam, was isolated from an actinomycete, Streptomyces sp., associated with the mud dauber, Sceliphron caementarium. Sceliphrolactam's structure was determined by 1D- and 2D-NMR, MS, UV, and IR spectral analysis. Sceliphrolactam displays antifungal activity against amphotericin B-resistant Candida albicans (MIC = 4 μg/mL, 8.3 μM).

PMID:
21247188
PMCID:
PMC3037738
DOI:
10.1021/ol102991d
[Indexed for MEDLINE]
Free PMC Article
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