Format

Send to

Choose Destination
See comment in PubMed Commons below
EMBO Mol Med. 2011 Feb;3(2):78-88. doi: 10.1002/emmm.201000114. Epub 2011 Jan 19.

To live or to die: a matter of processing damaged DNA termini in neurons.

Author information

1
MRC Genome Damage and Stability Centre, University of Sussex, Brighton, UK. smfame20@sussex.ac.uk

Abstract

Defects in the repair of deoxyribonucleic acid (DNA) damage underpin several hereditary neurological diseases in humans. Of the different activities that repair chromosomal DNA breaks, defects in resolving damaged DNA termini are among the most common causes of neuronal cell death. Here, the molecular mechanisms of some of the DNA end processing activities are reviewed and the association with human neurodegenerative disease is discussed.

PMID:
21246735
PMCID:
PMC3377058
DOI:
10.1002/emmm.201000114
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Support Center