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Genes Dev. 2011 Jan 15;25(2):131-6. doi: 10.1101/gad.610511.

Planar polarization of the atypical myosin Dachs orients cell divisions in Drosophila.

Author information

1
Apoptosis and Proliferation Control Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, United Kingdom.

Abstract

Tissues can grow in a particular direction by controlling the orientation of cell divisions. This phenomenon is evident in the developing Drosophila wing epithelium, where the tissue becomes elongated along the proximal-distal axis. We show that orientation of cell divisions in the wing requires planar polarization of an atypical myosin, Dachs. Our evidence suggests that Dachs constricts cell-cell junctions to alter the geometry of cell shapes at the apical surface, and that cell shape then determines the orientation of the mitotic spindle. Using a computational model of a growing epithelium, we show that polarized cell tension is sufficient to orient cell shapes, cell divisions, and tissue growth. Planar polarization of Dachs is ultimately oriented by long-range gradients emanating from compartment boundaries, and is therefore a mechanism linking these gradients with the control of tissue shape.

PMID:
21245166
PMCID:
PMC3022259
DOI:
10.1101/gad.610511
[Indexed for MEDLINE]
Free PMC Article

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