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Trends Cardiovasc Med. 1993 Jan-Feb;3(1):12-7. doi: 10.1016/1050-1738(93)90022-X.

Troponin isoform switching in the developing heart and its functional consequences.

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Department of Biomedical Sciences, CNR Unit for Muscle Biology and Physiopathology, University of Padova, 35121 Padova, Italy.


The subunits of the troponin complex-troponin C, troponin T, and troponin I-are responsible for the Ca(2+)-dependent regulation of contractile activity in heart and skeletal muscle. Distinct troponin T and I isoforms, generated by different genes or by alternative splicing from the same gene, are expressed during cardiac development. Troponin switching affects the Ca(2+) sensitivity of the contractile system and may account for the greater resistance to hypoxia and acidosis, and the impaired responsiveness to adrenergic stimulation of the fetal and neonatal heart.

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