Send to

Choose Destination
See comment in PubMed Commons below
Trends Cardiovasc Med. 1994 Mar-Apr;4(2):77-83. doi: 10.1016/1050-1738(94)90013-2.

Thrombin receptor function and cardiovascular disease.

Author information

Cardiovascular Research Institute, University of California, San Francisco, CA 94143-0524, USA.


Thrombin, a multifunctional protease generated at sites of vascular injury, is a powerful agonist fora variety of cellular processes important in cardiovascular disease. A recently cloned thrombin receptor has provided a framework for understanding how thrombin, a protease rather than a classic ligand, activates cells. It has also yielded new tools for defining the role of thrombin and its receptor in cellular events. This review discusses a working model for how thrombin activates platelets and other cells, and possible roles for the thrombin receptor in thrombotic, proliferative, and inflammatory processes.

PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center