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Pediatr Radiol. 2011 Jul;41(7):848-57. doi: 10.1007/s00247-010-1970-6. Epub 2011 Jan 18.

Accuracy of CT-guided percutaneous core needle biopsy for assessment of pediatric musculoskeletal lesions.

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1
Department of Radiology, C. S. Mott Children's Hospital, University of Michigan, Ann Arbor, MI, USA. anastasia.hryhorczuk@childrens.harvard.edu

Abstract

BACKGROUND:

CT-guided percutaneous core needle biopsy has been shown in adults to be an effective diagnostic tool for a large number of musculoskeletal malignancies.

OBJECTIVE:

To characterize our experience with CT-guided percutaneous core needle biopsy of pediatric bone lesions and determine its utility in diagnosing pediatric osseous lesions, in a population where such lesions are commonly benign.

MATERIALS AND METHODS:

From 2000 to 2009, 61 children underwent 63 CT-guided percutaneous biopsies. Radiological, pathological and clinical records were reviewed.

RESULTS:

Fourteen biopsies (22%) were performed on malignant lesions, while 49 biopsies (78%) were performed on benign lesions. Forty-nine of the 63 biopsies (78%) were adequate; these children underwent no further tissue sampling. Fourteen of the 63 biopsies (22%) were inadequate or non-conclusive. Of these patients, 12 underwent open biopsy. Retrospective analysis of percutaneous biopsies in these patients demonstrates that 9/12 provided clinically relevant information, and 4/12 patients received final diagnoses that confirmed initial core biopsy findings. No malignancies were diagnosed as benign on percutaneous biopsy. Overall, percutaneous core needle biopsy provided accurate diagnostic information in 84% (53/63) of biopsies.

CONCLUSION:

Our results demonstrate that CT-guided percutaneous biopsy is safe and beneficial in children. This study supports the use of CT-guided percutaneous core needle biopsy for primary diagnosis of pediatric bone lesions.

PMID:
21243347
DOI:
10.1007/s00247-010-1970-6
[Indexed for MEDLINE]
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