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Int J Biochem Cell Biol. 2011 Apr;43(4):474-7. doi: 10.1016/j.biocel.2011.01.005. Epub 2011 Jan 15.

Enhancer of zeste homolog 2: A potential target for tumor therapy.

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  • 1College of Life Sciences, Zhejiang University, 388 Yuhangtang Road, Hangzhou, Zhejiang Province, 310058, PR China.


Enhancer of zeste homolog 2 (EZH2) is a subunit of the Polycomb-Repressive Complex 2 (PRC2), which catalyses the trimethylation of histone H3 on Lys 27 (H3K27) and involves in genes repression. EZH2 is amplified and overexpressed in a variety of cancers, including prostate and breast cancer. Overexpression of EZH2 has been associated with the invasion and progression of malignant cancers, especially with the progression of prostate cancer. Here, we review the structure and biological function of EZH2, especially focused on its activities in the tumorigenesis.

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