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BMC Musculoskelet Disord. 2011 Jan 17;12:18. doi: 10.1186/1471-2474-12-18.

Hyperadiponectinemia enhances bone formation in mice.

Author information

1
Department of Orthopedic Surgery, Kurume University, Kurume, Fukuoka, Japan.

Abstract

BACKGROUND:

There is growing evidence that adiponectin, a physiologically active polypeptide secreted by adipocytes, controls not only adipose tissue but also bone metabolism. However, a role for adiponectin in bone development remains controversial.

METHODS:

We therefore investigated the endocrine effects of adiponectin on bone metabolism using 12-week-old male transgenic (Ad-Tg) mice with significant hyperadiponectinemia overexpressing human full-length adiponectin in the liver.

RESULTS:

In Ad-Tg mice, the serum level of osteocalcin was significantly increased, but the levels of RANKL, osteoprotegerin, and TRAP5b were not. Bone mass was significantly greater in Ad-Tg mice with increased bone formation. In contrast, bone resorption parameters including the number of osteoclasts and eroded surface area did not differ between Ad-Tg and their littermates.

CONCLUSIONS:

These findings demonstrate that hyperadiponectinemia enhances bone formation in mice.

PMID:
21241476
PMCID:
PMC3029226
DOI:
10.1186/1471-2474-12-18
[Indexed for MEDLINE]
Free PMC Article

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