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FEMS Microbiol Immunol. 1990 Sep;2(2):75-82.

Effect of gamma-interferon on phagosome-lysosome fusion in Salmonella typhimurium-infected murine macrophages.

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1
Department of Microbiology, Meiji College of Pharmacy, Nozawa, Tokyo, Japan.

Abstract

Effect of recombinant gamma-interferon (rIFN-gamma) on phagosome-lysosome fusion in Salmonella typhimurium-infected murine macrophages was examined. rIFN-gamma enhanced phagosome-lysosome fusion in macrophages infected with S. typhimurium in a dose-dependent manner, and over a range of 10(2) to 10(3) U/ml of rIFN-gamma exhibited maximum phagosome-lysosome fusion, although phagocytosis was slightly decreased. The enhancement of phagosome-lysosome fusion occurred greater than 3 h post-treatment with rIFN-gamma. Furthermore, the macrophage activation for phagosome-lysosome fusion was found to persist for 4 days even when rIFN-gamma had been removed. These results demonstrate that IFN-gamma may serve as a mediator for the activation of phagosome-lysosome fusion in murine macrophages.

[Indexed for MEDLINE]

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