Format

Send to

Choose Destination
See comment in PubMed Commons below
J Rheumatol. 2011 Apr;38(4):702-5. doi: 10.3899/jrheum.100754. Epub 2011 Jan 15.

Antinuclear antibodies and clinical associations in a british cohort with limited cutaneous systemic sclerosis.

Author information

1
Bangor University, Bangor, UK.

Abstract

OBJECTIVE:

To assess the prevalence of disease-specific autoantibodies in patients with limited cutaneous systemic sclerosis (lcSSc).

METHODS:

Sera from 180 patients with lcSSc were analyzed for antinuclear antibody (ANA). Clinical characteristics were compared in the presence or absence of specific autoantibodies.

RESULTS:

SSc-specific antibodies were detected in 135 patients (75%). Associations were found between anticentromere antibody and age at lcSSc diagnosis, telangiectasia, reduced creatinine clearance, and selective reduction in DLCO, and between antitopoisomerase-I and pulmonary fibrosis.

CONCLUSION:

The majority of patients with lcSSc belong to distinctive serologic subsets, potentially with prognostic significance.

PMID:
21239752
DOI:
10.3899/jrheum.100754
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center