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Cancer Epidemiol Biomarkers Prev. 2011 Mar;20(3):419-27. doi: 10.1158/1055-9965.EPI-10-1025. Epub 2011 Jan 14.

Plasma isoflavones and the risk of lung cancer in women: a nested case-control study in Japan.

Author information

1
Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, Tokyo, 104-0045 Japan. tshimazu@ncc.go.jp

Abstract

BACKGROUND:

Although several epidemiologic studies have found that isoflavone intake assessed by questionnaire is associated with a decreased risk of lung cancer, no prospective study has investigated this association using blood concentrations of isoflavones.

METHODS:

We conducted a nested case-control study within a population-based prospective cohort study. A total of 24,127 women aged 40 to 69 years who returned the baseline questionnaire and provided blood samples were observed from 1990 through 2006. During a median follow-up period of 13.5 years, 126 newly diagnosed lung cancer cases were identified. For each case, we selected two controls matched for age, area, smoking status, and condition of blood draw. A conditional logistic regression model was used to estimate the odds ratios (ORs) and 95% CIs of lung cancer in relation to plasma concentrations of genistein, daidzein, glycitein, equol, and total isoflavones.

RESULTS:

After exclusion of 20 lung cancer cases diagnosed in the first 3 years after blood collection, an inverse association was found between plasma genistein concentration and lung cancer risk. The multivariate-adjusted OR (95% CI) of lung cancer in the highest quintile of plasma genistein concentration as compared with that in the lowest quintile was 0.31 (0.12, 0.86; P for trend=0.085). Other isoflavones and total isoflavones were not associated with a significant decrease in the risk of lung cancer.

CONCLUSION:

Plasma genistein concentration was inversely associated with lung cancer risk in Japanese women.

IMPACT:

Our data support the previously observed association between isoflavone intake and lung cancer risk.

PMID:
21239686
DOI:
10.1158/1055-9965.EPI-10-1025
[Indexed for MEDLINE]
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