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Trends Mol Med. 2011 Mar;17(3):166-74. doi: 10.1016/j.molmed.2010.12.001. Epub 2011 Jan 13.

Understanding the role of SOX9 in acquired diseases: lessons from development.

Author information

1
Endocrinology and Diabetes Group, School of Biomedicine, Manchester Academic Health Sciences Centre, University of Manchester, Manchester M13 9PT, UK.

Abstract

The transcription factor SOX9 is crucial for multiple aspects of development. Mutations in SOX9 cause campomelic dysplasia, a haploinsufficiency disorder concordant with the expression profile of SOX9 during embryogenesis. The mechanistic understanding of development has revealed roles for SOX9 in regulating cartilage extracellular matrix (ECM) production and cell proliferation, among others. More recently, it transpires that SOX9 becomes expressed and induces destructive ECM components in organ fibrosis and related disorders. Although commonly absent from the parent cell type, SOX9 is expressed in a wide range of cancers, where it regulates cell proliferation. These data have potential diagnostic, prognostic and therapeutic relevance, suggesting that disease mechanisms might result from re-expressing this developmental transcription factor in ectopic locations.

PMID:
21237710
DOI:
10.1016/j.molmed.2010.12.001
[Indexed for MEDLINE]

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