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Eur J Radiol. 2012 Feb;81(2):286-91. doi: 10.1016/j.ejrad.2010.12.010. Epub 2011 Jan 14.

The value of strain ratio in differential diagnosis of thyroid solid nodules.

Author information

1
Department of Ultrasound, Second Affiliated Hospital of Harbin Medical University, Harbin 150081, PR China.

Abstract

OBJECTIVE:

To assess the clinical value of strain ratio in differentiating thyroid solid nodules and explore its distribution characters based on pathological results.

MATERIALS AND METHODS:

The study was approved by the ethic committee and the informed consents were signed. Ninety nine solid thyroid nodules (67 benign and 32 malignant) from 71 female (mean age 46.3 ± 9.8 years) and 28 male (mean age 54.9 ± 11.7 years) patients were evaluated. Five radiologists evaluated the nodules based on a four-degree elastography score system. Strain ratio was calculated on-line. Diagnostic performances of the two evaluations were compared using Receiver Operating Characteristic (ROC) curves. Values of different pathological nodules were compared by one-way ANOVA.

RESULTS:

Areas under the ROC curve (AUC) of the five readers were 0.82, 0.81, 0.79, 0.73 and 0.83, respectively. The AUC of strain ratio evaluation was higher (0.88 vs. 0.79, p < 0.001) than that of the ES score evaluation. Best cut-off points of the two evaluations were 3.5 (82% sensitivity, 72% specificity) and 4.225 (81% sensitivity, 83% specificity), respectively. Both the ES score and strain ratio were higher for malignant nodules than that for benign ones (p < 0.001).

CONCLUSIONS:

Strain ratio was a useful index in differential diagnosis of thyroid solid nodules. It can provide quantitative information on thyroid nodule characterization and improve diagnostic confidence. The best cut-off point for benign and malignant nodules was 4.2.

PMID:
21237598
DOI:
10.1016/j.ejrad.2010.12.010
[Indexed for MEDLINE]

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