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Gastrointest Endosc. 2011 Apr;73(4):718-26. doi: 10.1016/j.gie.2010.10.053. Epub 2011 Jan 14.

Direct endoscopic necrosectomy for the treatment of walled-off pancreatic necrosis: results from a multicenter U.S. series.

Author information

1
Section of Gastroenterology and Hepatology, Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA.

Abstract

BACKGROUND:

Direct endoscopic necrosectomy (DEN) for treatment of walled-off pancreatic necrosis (WOPN) has been performed as an alternative to operative or percutaneous therapy.

OBJECTIVE:

To report the largest combined experience of DEN performed for WOPN.

DESIGN:

Retrospective chart review.

SETTING:

Six U.S. tertiary medical centers.

PATIENTS:

A total of 104 patients with a history of acute pancreatitis and symptomatic WOPN since 2003.

INTERVENTIONS:

DEN for WOPN.

MAIN OUTCOME MEASUREMENTS:

Resolution or near-resolution of WOPN without the need for surgical or percutaneous intervention and procedural complications.

RESULTS:

Successful resolution was achieved in 95 of 104 patients (91%). Of the patients in whom it failed, 5 died during follow-up before resolution, 2 underwent operative drainage for persistent WOPN, 1 required surgery for massive bleeding on fistula tract dilation, and 1 died periprocedurally. The mean time to resolution from the initial DEN was 4.1 months. The first débridement was performed a mean of 63 days after the initial onset of acute pancreatitis. In 73%, the entry was transgastric with median tract dilation diameter of 18 mm. The median number of procedures was 3 with 2 débridements. Complications occurred in approximately 14% and included 5 retrogastric perforations/pneumoperitoneum, which were managed nonoperatively. Univariate analysis identified a body mass index >32 as a risk factor for failed DEN.

LIMITATIONS:

Retrospective, highly specialized centers.

CONCLUSIONS:

This large, multicenter series demonstrates that transmural, minimally invasive endoscopic débridement of WOPN performed in the United States is an efficacious and reproducible technique with an acceptable safety profile.

PMID:
21237454
DOI:
10.1016/j.gie.2010.10.053
[Indexed for MEDLINE]

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