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Antioxid Redox Signal. 2011 May 1;14(9):1659-74. doi: 10.1089/ars.2010.3841. Epub 2011 Mar 16.

The specificity of nitroxyl chemistry is unique among nitrogen oxides in biological systems.

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1
Radiation Biology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

Abstract

The importance of nitric oxide in mammalian physiology has been known for nearly 30 years. Similar attention for other nitrogen oxides such as nitroxyl (HNO) has been more recent. While there has been speculation as to the biosynthesis of HNO, its pharmacological benefits have been demonstrated in several pathophysiological settings such as cardiovascular disorders, cancer, and alcoholism. The chemical biology of HNO has been identified as related to, but unique from, that of its redox congener nitric oxide. A summary of these findings as well as a discussion of possible endogenous sources of HNO is presented in this review.

PMID:
21235346
PMCID:
PMC3070000
DOI:
10.1089/ars.2010.3841
[Indexed for MEDLINE]
Free PMC Article
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