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Int Rev Immunol. 2011 Feb;30(1):4-15. doi: 10.3109/08830185.2010.522281.

Control of NF-κB and inflammation by the unfolded protein response.

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1
Department of Molecular Signaling, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, Japan. masanori@yamanashi.ac.jp

Abstract

Under inflammatory situations, endoplasmic reticulum (ER) stress occurs at local sites and modulates inflammatory processes. NF-κB is a key regulator for immune and inflammatory responses, and its activity is influenced by ER stress positively or negatively. Recent investigation suggested that ER stress induces activation of NF-κB in the early phase, whereas in the later phase, consequent unfolded protein response (UPR) inhibits NF-κB. This review summarizes current knowledge on potential mechanisms underlying the biphasic, bidirectional regulation of NF-κB by the UPR and possible roles for ER stress in the regulation of inflammation.

PMID:
21235322
DOI:
10.3109/08830185.2010.522281
[Indexed for MEDLINE]
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