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Ophthalmology. 2011 Jun;118(6):1201-4. doi: 10.1016/j.ophtha.2010.10.002. Epub 2011 Jan 12.

Giant cell arteritis: laboratory predictors of a positive temporal artery biopsy.

Author information

1
PGY-2 Internal Medicine, University of California San Francisco-Fresno, Fresno, California 93701, USA. mwalvick@gmail.com

Abstract

PURPOSE:

To identify laboratory predictors of a positive temporal artery biopsy.

DESIGN:

Cross-sectional study using retrospective electronic data base review.

PARTICIPANTS:

There were 3001 patients who had a temporal artery biopsy.

METHODS:

The electronic database of a large health maintenance organization was searched for all patients who had a temporal artery biopsy performed from 1997 to 2006.

MAIN OUTCOME MEASURES:

Odds ratios for erythrocyte sedimentation rate, C-reactive protein (CRP), and platelet count values associated with a positive temporal artery biopsy.

RESULTS:

Four hundred fifty-nine cases of biopsy-proven giant cell arteritis were identified. The odds of a positive biopsy were 1.5 times greater with an erythrocyte sedimentation rate of 47 to 107 mm/hr, 5.3 times greater with a CRP >2.45 mg/dL, and 4.2 times greater with platelets >400,000/μL.

CONCLUSIONS:

In this largest population-based giant cell arteritis study in the United States to date, we reaffirm Hayreh's finding of the significance of a CRP level >2.45 mg/dL in predicting a positive biopsy. Our findings support the literature suggesting that CRP and thrombocytosis may be stronger predictors of positive biopsy than erythrocyte sedimentation rate.

FINANCIAL DISCLOSURE(S):

The authors have no proprietary or commercial interest in any of the materials discussed in this article.

PMID:
21232803
DOI:
10.1016/j.ophtha.2010.10.002
[Indexed for MEDLINE]

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