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Radiol Phys Technol. 2011 Jul;4(2):109-20. doi: 10.1007/s12194-010-0110-1. Epub 2011 Jan 13.

Effectiveness of temporal and dynamic subtraction images of the liver for detection of small HCC on abdominal CT images: comparison of 3D nonlinear image-warping and 3D global-matching techniques.

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Department of Medical Radiological Technology, Kagoshima Medical Technology College, 5417-1 Hirakawa, Kagoshima, Japan.


Misregistration errors occur at the periphery of the hepatic region due to respiratory- and interval-related changes in hepatic shape. To reduce these misregistration errors, we developed a temporal and dynamic subtraction technique to enhance small hepatocellular carcinoma (HCC) by using a 3D nonlinear image-warping technique. The study population consisted of 21 patients with HCC. We registered the present and previous arterial-phase CT images or the present nonenhanced and arterial-phase CT images obtained in the same position by 3D global-matching plus 3D nonlinear image-warping. Temporal subtraction images were obtained by subtraction of the previous arterial-phase CT image from the warped present arterial-phase CT image. Dynamic subtraction images were obtained by subtraction of the present nonenhanced CT image from the warped present arterial-phase CT image. When we used this new technique, the number of good or excellent cases increased from 14.2% (3/21 cases) to 71.4% (15/21 cases) on temporal subtraction images. With this technique, subjective rating scores for image quality improved in 57.1% of cases (12/21 cases) on temporal subtraction images and 81.0% of cases (17/21 cases) on dynamic subtraction images. The results indicated that the new subtraction images were greatly improved by use of the 3D nonlinear image-warping technique.

[Indexed for MEDLINE]

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