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Inflamm Res. 2011 Apr;60(4):309-19. doi: 10.1007/s00011-010-0302-5. Epub 2011 Jan 13.

Effect of marine n-3 fatty acids on circulating inflammatory markers in healthy subjects and subjects with cardiovascular risk factors.

Author information

1
Faculty of Health, Nutrition and Management, Akershus University College, PO box 423, 2001, Lillestrøm, Norway.

Abstract

OBJECTIVE:

The aim of the present paper was to review the literature in order to summarize the effects of marine n-3 fatty acids on circulating inflammatory markers among healthy subjects, subjects with high risk of developing cardiovascular disease (CVD) and in patients with CVD in human intervention studies.

METHODS:

A systematic literature search in PubMed was performed. Intervention studies describing the effects of marine n-3 fatty acids on circulating inflammatory markers in healthy subjects, subjects with high risk of CVD and patients with CVD were included. The following exclusion criteria were used: (1) interventions assessing inflammatory markers with ex vivo methods (2) interventions with children (3) articles describing animal or cell culture studies. Twenty-two articles were included. Additionally, 13 papers from their literature lists were included based on the same inclusion and exclusion criteria as the literature search.

RESULTS AND CONCLUSION:

Intervention studies with marine n-3 fatty acids administered from either fish or fish oil demonstrate different results on inflammatory markers. No firm conclusion can be drawn about the effect of marine n-3 fatty acids on circulating inflammatory markers in healthy individuals, individuals with high risk of developing CVD or individuals with CVD related diseases.

PMID:
21229287
PMCID:
PMC3058501
DOI:
10.1007/s00011-010-0302-5
[Indexed for MEDLINE]
Free PMC Article

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