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Korean J Radiol. 2011 Jan-Feb;12(1):66-77. doi: 10.3348/kjr.2011.12.1.66. Epub 2011 Jan 3.

Serial MR imaging of intramuscular hematoma: experimental study in a rat model with the pathologic correlation.

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1
Department of Radiology, Daejeon St. Mary's Hospital, The Catholic University of Korea, Daejeon 301-723, Korea.

Abstract

OBJECTIVE:

We wanted to demonstrate the temporal changes of the magnetic resonance imaging (MRI) findings in experimentally-induced intramuscular hematomas in rats and to correlate these data with the concurrent pathologic observations.

MATERIALS AND METHODS:

Intramuscular hematoma was induced in 30 rats. The MR images were obtained at 1, 4, 7 and 10 days and at 2, 3, 4, 6 and 8 weeks after muscle injury. The characteristic serial MRI findings were evaluated and the relative signal intensities were calculated. Pathologic specimens were obtained at each time point.

RESULTS:

On the T1-weighted imaging (T1WI), the intramuscular hematomas exhibited isointensity compared to that of muscle or the development of a high signal intensity (SI) rim on day one after injury. The high SI persisted until eight weeks after injury. On the T2-weighted imaging (T2WI), the hematomas showed high SI or centrally low SI on day one after injury, and mainly high SI after four days. A dark signal rim was apparent after seven days, which was indicative of hemosiderin on the pathology. The gradient echo (GRE) imaging yielded dark signal intensities at all stages.

CONCLUSION:

Unlike brain hematomas, experimentally-induced intramuscular hematomas show increased SI on both the T1WI and T2WI from the acute stage onward, and this is pathologically correlated with a rich blood supply and rapid healing response to injury in the muscle. On the T2WI and GRE imaging, high SI with a peripheral dark signal rim is apparent from seven days to the chronic stage.

KEYWORDS:

Hematoma; Magnetic resonance (MR); Muscle; Pathology; Rat model

PMID:
21228942
PMCID:
PMC3017886
DOI:
10.3348/kjr.2011.12.1.66
[Indexed for MEDLINE]
Free PMC Article
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