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Kidney Int. 2011 Feb;79(3):269-71. doi: 10.1038/ki.2010.434.

Angiotensin II: breathtaking in the renal medulla.

Author information

1
Division of Nephrology and Hypertension, Departments of Medicine, Vanderbilt School of Medicine, Nashville, Tennessee 37232, USA. volker.haase@vanderbilt.edu

Abstract

Angiotensin II (Ang II) is a major contributor to the progression of renal fibrosis. Wang and colleagues provide evidence that signaling through the prolyl-4-hydroxylase domain (PHD)-hypoxia-inducible factor-1 (HIF-1) pathway mediates profibrotic effects of Ang II in rat renal medullary interstitial cells under normoxic conditions, thus placing the HIF oxygen-sensing pathway into the center of an Ang II-induced profibrotic signaling cascade.

PMID:
21228800
PMCID:
PMC3621768
DOI:
10.1038/ki.2010.434
[Indexed for MEDLINE]
Free PMC Article

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