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Blood Purif. 2011;31(1-3):146-50. doi: 10.1159/000321859. Epub 2011 Jan 10.

Sleep disorders over the full range of chronic kidney disease.

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Department of Nephrology, Humber River Regional Hospital, University of Toronto, Toronto, Ontario, Canada.


Sleep disorders are common and underrecognized in patients at all stages of chronic kidney disease. They include sleep apnea, insomnia, excessive sleepiness, restless legs syndrome and periodic limb movement disorder. They can be related to underlying uremia or comorbidities. Sleep disorders can affect the quality of life, and some are associated with increased morbidity and mortality. Clinical assessment, polysomnography and other standardized assessments are required for diagnosis. Therapeutic approaches include improvement in uremia management, treatment of comorbidities or specific interventions directed at individual sleep disorders. Diagnosis and treatment of sleep disorders in this population may improve quality of life and patient survival.

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