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Traffic. 2011 Jun;12(6):657-64. doi: 10.1111/j.1600-0854.2011.01163.x. Epub 2011 Feb 8.

SNARE proteins underpin insulin-regulated GLUT4 traffic.

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Henry Wellcome Laboratory of Cell Biology, Institute of Molecular, Cell and Systems Biology, Davidson Building, College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8QQ, UK.


Delivery of the glucose transporter type 4 (GLUT4) from an intracellular location to the cell surface in response to insulin represents a specialized form of membrane traffic, known to be impaired in the disease states of insulin resistance and type 2 diabetes. Like all membrane trafficking events, this translocation of GLUT4 requires members of the SNARE family of proteins. Here, we discuss two SNARE complexes that have been implicated in insulin-regulated GLUT4 traffic: one regulating the final delivery of GLUT4 to the cell surface in response to insulin and the other controlling GLUT4's intracellular trafficking.

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