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Nihon Rinsho. 2011 Jan;69(1):34-8.

[Roles of lipid mediators in controlling vascular inflammation and the progression of atherosclerosis].

[Article in Japanese]

Author information

1
Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo.

Abstract

Atherosclerosis is recognized as an inflammatory condition of the vessel wall, characterized by accumulation of inflammatory cells such as macrophages and T cells. There are accumulating evidences that chemokines, cytokines, and lipid mediators coordinately modulate platelet- or leukocyte-endothelial cell interactions, and contribute to the maintenance of vascular homeostasis. This review focuses on the role of lipid mediators, especially those derived from polyunsaturated fatty acids, in controlling vascular inflammation and the progression of atherosclerosis.

PMID:
21226257
[Indexed for MEDLINE]

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